Figure 2. BRAF inhibitors increase the clonality of tumor-infiltrating lymphocytes. (A) Changes in clonality of tumor-infiltrating lymphocytes (TILs) 10–14 d after the initiation of BRAF inhibitors are shown as fold change as compared with pre-treatment values, as a box and whiskers plot (n = 8 patients). The bottom and top of the box represent the 25th and 75th percentile, respectively, while the bar indicates the median value. (B) Percentage of the total TIL population occupied by the 5%, 2.5%, 1%, and 0.5% dominant TIL clones. Patient samples are sorted along the X-axis based on their maximal response to treatment. CR, complete response; PR, partial response; SD, stable disease.