Table 1. Clinicopathological characteristics (N=298).
|
HS3ST2 hypermethylation |
||||
|---|---|---|---|---|
| Category | Subcategory | No (N=203) | Yes (N=95) | P-value |
| Agea | 62 ± 8 | 60 ± 11 | 0.12 | |
| Pack-yearsa | 26 ± 24 | 32 ± 25 | 0.01 | |
| Size (cm)a | 3.9 ± 1.9 | 4.3 ± 2.1 | 0.14 | |
| Sex | Women | 45 | 26 | |
| Men | 158 | 69 | 0.33 | |
| Smoking status | Never | 73 | 15 | |
| Former | 32 | 17 | ||
| Current | 98 | 63 | 0.002 | |
| Histology | Adenob | 77 | 48 | |
| Squamousb | 107 | 39 | ||
| Others | 19 | 8 | 0.12 | |
| Differentiationc | Well | 25 | 17 | |
| Moderately | 95 | 37 | ||
| Poorly | 29 | 18 | ||
| Undifferentiated | 7 | 2 | 0.31 | |
| Pathologic stage | I | 118 | 58 | |
| II | 53 | 19 | ||
| III | 30 | 17 | ||
| IV | 2 | 1 | 0.66 | |
| Recurrence | No | 110 | 59 | |
| Yes | 93 | 36 | 0.20 | |
a
Mean ± standard deviation
b
Adeno, adenocarcinoma; squamous, squamous cell carcinoma
c
Differentiation data are missing in 68 cases