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. 2013 Nov 12;8(11):e79092. doi: 10.1371/journal.pone.0079092

Table 2. Known platypus venom proteins and their homologs in the echidna transcriptome.

Platypus toxin Ancestral activity Derived activity Expressed in echidna gland
Defensin-likepeptides Antimicrobial Unknown No
Nerve growthfactor Regulation of nerve growth and differentiation; Hyperalgaesia Possibly hyperalgaesia No
C-type natriureticpeptide-like Natriuretic, diuretic and vasodilatory functions associatedwith homeostasis and blood pressure control andregulates the growth and differentiation ofcartilaginous growth plate chondrocytes Relaxant, oedema-producing andmast-cell degranulatingactivities No
Hyaluonidase Increase tissue permeability by lowering the viscosity of hyaluronan– roles in reproduction Believed to accelerate the spread oftoxins and hemostatic factorsin toxin No
Amide oxidase Function in cell differentiation, growth, wound healing,detoxification, cell signaling May cause platelet aggregation,assist in haemorrhage andcell death Yes
Peptidoglycanrecognitionprotein-1 Antimicrobial Unknown No
Serpin Blood coagulation, complement activation, fibrinolysis,angiogenesis, inflammation, tumour suppression andhormone transport Possible role in blood coagulationand hypertension No
Kunitz-domaincontaining serineprotease inhibitor Involved in hemostasis Possible role in disrupting hemostasis Yes
Nucleobindin Stimulates autonomic nervous system activity, increasesblood pressure, induces fear in rats May induce the fear response in victim No
Differentiationfactor-15 Regulates the inflammatory response and apoptosis May function to induce pain No
CXC-chemokine Chemotactic, mediate cell growth and triggers aninflammatory response Unknown No
Complement decay-acceleration factor Inhibits complement-mediated lysis Unknown Yes
L-D-amino-acid-residue isomerase Unknown Interconverts the second amino-acidresidue of venom peptides betweenthe L-form and D-form No
Corticotropin-releasingfactor-binding protein Linked to behavioural and psychological changes andnerve signalling Suggested to increase submissive behaviourin victim linked to role of venomfor intraspecific competition Yes