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. 2013 Nov 12;8(11):e79601. doi: 10.1371/journal.pone.0079601

Figure 1. Differences in TV-DTH reactivity pre-transplant to col(V) in patients with end-stage lung disease by disease type and by prevalence of DRB1*1501.

Figure 1

A significant number of patients with IPF had col(V) reactivity (net swelling ≥ 25 x 10-4 inches, dotted line; *ANOVA p<0.0007). Independently, patients with DRB1*1501 (red symbols) were enriched in col(V) responders (net swelling ≥ 25 x10-4 inches, Chi Square p= 0.01). AAD - α1 -antitrypsin disease; CF - cystic fibrosis; COPD - chronic obstructive pulmonary disease; IPF - idiopathic pulmonary fibrosis. Patients with lung diseases: n=53 (previous publication, [14]), n=45 new subjects, and n=1 subject who donated samples to both studies (average values of 2 time-points). Healthy subjects (n=14) with known HLA-DR types were tested and used as controls.