Figure 2. TYY cyclic peptide selectively inhibits Eph4-ephrinA5 interactions.

For ephrinA5 AP binding to immobilized EphA4 Fc fusion protein, TYY shows 94% inhibition at 100 μM, but 30% or even lower inhibition for ephrinB2 AP binding to immobilized EphB receptor Fc fusion proteins (EphB1, B2, B3, and B4). The histogram shows the inhibition of each ephrin AP bound to their Eph receptors. Error bars represent standard errors from three independent measurements.