. 2013 Nov 12;8(11):e81275. doi: 10.1371/journal.pone.0081275

Table 1. IC₅₀ values of Foretinib, Foretinib-TCO (11), and Foretinib-BODIPY-FL (12) for the indicated recombinant human kinases.

Compound	MET	AXL	RON	PDGFRα	KDR
Foretinib	28.7	21.4	20.2	59.2	24.3
Foretinib-TCO	88.6	72.5	82.7	264.6	149.9
Foretinib-BODIPY-FL	697.4	ND	ND	ND	ND
Fold Change (TCO/Foretinib)	3.1	3.4	4.1	4.5	6.2

All IC₅₀ values are in nM and R² values for the dose-response curve fit (GraphPad, Prism) were 0.92 or greater. Fold change is Foretinib-TCO (11) IC₅₀ value divided by Foretinib IC₅₀ value. ND: not determined.

Table 1. IC50 values of Foretinib, Foretinib-TCO (11), and Foretinib-BODIPY-FL (12) for the indicated recombinant human kinases.

Table 1. IC₅₀ values of Foretinib, Foretinib-TCO (11), and Foretinib-BODIPY-FL (12) for the indicated recombinant human kinases.