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. 2013 Nov 12;8(11):e80840. doi: 10.1371/journal.pone.0080840

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© 2013 Ellis et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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This diagram shows the various chimeric viruses and deletion mutants generated. Black represents sequences from JCV_Mad-1 and white represents sequences from JCV_CPN. Lines represent DNA sequences. Dotted Lines represent deletions. Boxes represent genes. An X through ATG represents mutation of the start codon to eliminate protein expression. Mad-1 C-Agno is JCV_Mad-1 with the JCV_CPN agnogene introduced. CPN M-Agno is JCV_CPN with a full length agnogene from JCV_Mad-1 introduced. Mad-1 C-RR is JCV_Mad-1 with the JCV_CPN RR and CPN M-RR is JCV_CPN with the JCV_Mad-1 RR. Mad-1 Pt is JCV_Mad-1 with a mutated start codon which prevents the expression of the agnoprotein and Mad-1 Del is JCV_Mad-1 with the entire agnogene deleted. CPN M-Pt is JCV_CPN with the agnogene of Mad-1 Pt.