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. 2013 Nov 13;8(11):e78727. doi: 10.1371/journal.pone.0078727

Figure 7. NOC7 increases the excitability of B19 neurons.

Figure 7

A: Comparison of action potentials evoked by injecting depolarizing current (+20 pA, 1 s) before and after treatment with NOC7 (100 µM). Note that one more AP was induced after NOC7 application. B: Evoked APs in response to +100 pA current injection for 1 s before and after treatment with NOC7 (100 µM). Note that NOC7 application resulted in shortened inter-spike intervals. C: Quantification of normalized spike frequency for vehicle controls and NOC7 groups. The frequency of evoked APs after treatment was normalized to that before treatment. In both +20 pA and +100 pA current injection conditions, NOC7 caused a significant increase in the frequency of evoked APs.