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. 2013 Nov 13;8(11):e78966. doi: 10.1371/journal.pone.0078966

Figure 4. BCG ΔureC::hly_hIL7 and BCG ΔureC::hly_hIL18 enhance antigen-specific Th1 responses.

Figure 4

Flow cytometric analysis of CD40L-expressing antigen-specific CD4+ T cell responses (A) and cytokine-producing CD40L+CD4+ T cells (B) in the lungs, spleen and draining (inguinal) lymph nodes (dLNs) of vaccinated mice following in vitro re-stimulation with M. tuberculosis H37Rv whole cell lysate. Only comparisons made with BCG ΔureC::hly are displayed. Shown are means ± SEM (n = 3 mice per group) analyzed using two-way ANOVA and Tukey’s post-hoc test; *p<0.05. Experiment was performed twice.