Table 1.
Eligibility criteria
| Inclusion criteria | |
|---|---|
| (1) |
Patients with acute isolated spinal cord injury (AIS A-D) planned for surgical stabilization and decompression, lesion may include more than 1 segment |
| (2) |
Patients with acute isolated spinal fracture planned for surgical stabilization, lesion may include more than 1 segment |
| (3) |
≥ 2 spinal cord or vertebral lesions definable one from another |
| (4) |
Legal age of the patient |
| (5) |
Documented informed consent of the patient |
|
Exclusion criteria | |
| (1) |
Non-traumatic spinal cord injury |
| (2) |
2 or more spinal cord or vertebral lesions definable one from another |
| (3) |
Severe polytrauma (definition: patients with severe injuries of life-sustaining organ systems, which per se and in the acute phase are life-threatening (e.g., severe pelvic trauma, severe body cavity injuries) |
| (4) |
Concomitant traumatic brain injury (TBI) (definition: i) Patients with persisting neurological deficit in consequence of the TBI, ii) patient with severe TBI (Glasgow Coma Scale ≤ 8), and iii) patients with intracranial pressure monitoring sensors.) |
| (5) |
Neoplasia and/or antineoplastic therapy |
| (6) |
Rheumatic disease, collagenosis, vasculitis or other autoimmune disease |
| (7) |
Preexisting chronic infectious disease (before the injury) |
| (8) |
Preexisting systemic steroid treatment |
| (9) |
Severe alcohol or drug addiction |
| (10) | Pregnancy, lactation |