Table 1. List of Randomised Controlled Trials for Depression and/or Anxiety in PD.
| Intervention Type | First Author (Year) | Treatment | Comparison | N |
| Antidepressant | Alca (2011) | Sertraline (SSRI) | Venlafaxine (SNRI) | 32 |
| Andersen (1980) | Nortriptyline (TCA) | Placebo | 22 | |
| Antonini (2006) | Sertraline (SSRI) | Amitriptyline (TCA) | 31 | |
| Avila (2003) | Nefazodone (SARI) | Fluoxetine (SSRI) | 16 | |
| Dell’Agnello (2001) | Fluoxetine (SSRI) | Fluvoxamine (SSRI) | 62 | |
| Citalopram (SSRI) | ||||
| Sertraline (SSRI) | ||||
| Devos (2008) | Citalopram (SSRI) | Placebo | 48 | |
| Desipramine (TCA) | ||||
| Djokic (2010) | Clomipramine (TCA) | Placebo | 339 | |
| Fluoxetine (SSRI) | ||||
| Sertraline (SSRI) | ||||
| Escitalopram (SSRI) | ||||
| Mirtazapine (NaSSa) | ||||
| Tianeptine (SSRE) | ||||
| Leentjens (2003) | Sertraline (SSRI) | Placebo | 12 | |
| Menza (2009) | Nortriptyline (TCA) | Placebo | 52 | |
| Paroxetine (SSRI) | ||||
| Rabey (1996) | Fluvoxamine (SSRI) | Amitriptyline (TCA) | 47 | |
| Richard (2012) | Paroxetine (SSRI) | Placebo | 115 | |
| Venlafaxine (SNRI) | ||||
| Serrano-Duenas (2002) | Fluoxetine (SSRI) | Amitriptyline (TCA) | 77 | |
| Trivedi (2003) | Sertraline (SSRI) | Bupropion | 46 | |
| Wermuth (1998) | Citalopram (SSRI) | Placebo | 18 | |
| Werneck (2009) | Trazodone (SARI) | Placebo | 20 | |
| Xia (2012) | Fluoxetine (SSRI) | Fluoxetine (SSRI) + Eelectroacupuncture | 60 | |
| Pharmacological | Barone (2006) | Pramipexole (DA) | Sertraline (SSRI) | 67 |
| (other) | Barone (2010) | Pramipexole (DA) | Placebo | 287 |
| Rektorova (2003) | Pramipexole (DA) | Pergolide (DA) | 41 | |
| Steur (1997) | Moclobemide (MAO-I) | Moclobemide + SSelegiline | 10 | |
| Weintraub (2010) | Atomoxetine (SNRI) | Placebo | 55 | |
| Supplements | Moralez Da Silva (2008) | Omega-3 fatty-acid | Placebo | 29 |
| rTMS | Boggio (2005) | Left prefrontal rTMS | Fluoxetine (SSRI) | 25 |
| Cardoso (2008) | Left prefrontal rTMS | Fluoxetine (SSRI) | 21 | |
| Fregni (2004) | Left prefrontal rTMS | Fluoxetine (SSRI) | 42 | |
| Fregni (2006) | Left prefrontal rTMS | Fluoxetine (SSRI) | 26 | |
| Pal (2010) | Left prefrontal rTMS | Placebo (sham rTMS) | 22 | |
| Psychotherapy | Dobkin (2011) | Individual CBT | Clinical monitoring | 80 |
| Veazey (2009) | Telephone CBT | Telephone counselling | 10 | |
TCA = tricyclic antidepressant, SSRI = selective serotonin reuptake inhibitor, SARI = serotonin 2 antagonist/reuptake inhibitor, DA = dopamine agonist, SNRI = selective norepinephrine reuptake inhibitor, rTMS = repetitive transcranial magnetic stimualation, CBT = cognitive behavioural therapy.