Table I.
Summary of the largest studies on the association between ABO blood group and thrombosis.
| First author, yearref. | Study design | End point | Patients/controls | Main results |
|---|---|---|---|---|
| Arterial thrombosis | ||||
|
| ||||
| Whincup, 199028 | Prospective | MI | 7,662/- | The incidence of MI was higher in group A subjects than in those with other blood groups (RR 1.21; 95% CI: 1.01–1.46) |
| Wiggins, 200929 | Case-control | MI | 1,063/3,452 | The A(11) allele was associated with an increased risk of MI (OR 1.23; 95% CI: 1.05–1.44) |
| IS | 469/3,452 | The B allele was associated with an increased risk of IS (OR 1.59; 95% CI: 1.17–2.17) | ||
| Carpeggiani, 201030 | Case-control | MI | 4,901/ND | Non-O blood group was associated with an increased risk of cardiac mortality (HR 1.53, 95% CI: 1.06–2.21) |
| Reilly, 201131 | Case-control | MI | 470/463 | Non-O blood group was associated with an increased risk of MI compared with that in the O blood group (OR 1.62; 95% CI: 1.23–2.13) |
|
| ||||
| Venous thrombosis | ||||
|
| ||||
| Koster, 199525 | Case-control | VTE | 301/301 | Non-O blood group was associated with an increased risk of VTE compared with that in the O blood group (adjusted OR 1.5; 95% CI: 1.0–2.2) |
| Morelli, 200532 | Case-control | VTE | 301/299 | Non-O blood group was associated with an increased risk of VTE compared with that in the O blood group (adjusted OR 1.4; 95% CI: 1.0–2.1) |
| Tirado, 200533 | Case-control | VTE | 250/250 | Non-O blood group was associated with an increased risk of VTE compared with that in the O blood group (adjusted OR 1.7; 95% CI: 1.1–2.6) |
| Ohira, 200726 | Case-control | VTE | 492/1,008 | Non-O blood group was associated with an increased risk of VTE compared with that in the O blood group (adjusted OR 1.31; 95% CI: 1.01–1.68) |
| Wiggins, 200929 | Case-control | VTE | 504/2,172 | Non-O blood group was associated with an increased VTE risk (HR 1.77, 95% CI: 1.43–2.18) |
| Spiezia, 201327 | Case-control | VTE | 712/712 | Having a non-O blood group increased the risk of VTE by 2.2 times (OR 2.21; 95% CI: 1.78–2.75) |
Legend MI: myocardial infarction; IS: ischaemic stroke; RR: relative risk; CI: confidence interval; ND: national distribution; HR: hazard ratio; OR: odds ratio; VTE: venous thromboembolism.