Figure 1. Establishment and basic features of the polygenic DU6 mouse model.

Body weight selection was performed over 146 generations beginning in 1976 (Fig 1A). Epididymal fat mass (Fig. 1B) in male DU6 mice from 7 to 39 weeks of age (n = 15; *: P<0.01; in 39-week DU6 mice: n = 9). Longitudinal consumption of chow food (Fig 1C) was assessed in male mice in 4 different age groups over a period of 7 days (6, 12, 18 and 24 weeks of age; n>12; *: P<0.01).