Figure 1. eNOS^-/- increased neurological functional deficits and axon damage, but not increased lesion volume in the ischemic brain 7 days after stroke.

Axon density is positively correlated with the functional outcome. A: Lesion volume; B: Single pellet reaching test; C: Bielshowsky silver- staining in the bundles of striatum and quantitative data; D: pNFH-immunostaining in the striatal bundles and quantitative data. E: Correlation analysis between single pellet reaching test and axon density. Scale bar in C = 50 µm; in D = 25 µm. *p<0.05, n = 12/group