Figure 5. Inhibition of the SDF-1/CXCR4-dependent lung metastases by treatment with mGluR5 antagonists.

Cells were inoculated into the blood vessel of nude mice, which were sacrificed on day 30. (A) Representative H&E staining of the lungs from control-treated (left), MPEP-treated (middle), MTEP-treated (right) nude mice. (B) Quantitative analysis by Alu-PCR was performed on the extirpated-lung tissues. **, p < 0.01 when compared to the saline control by one-way ANOVA.