Fig. 1.

Inhibition of the mTOR pathway decreased the lipid accumulation induced by inflammation in vivo and in vitro. ApoE KO mice were fed the Western diet for eight weeks and received either no treatment (Control, I and V) or were treated by injection with 10% casein (Casein, II and VI), 8 mg/kg/q.o.d rapamycin (Rapa, III and VII) or rapamycin plus casein (Rapa plus Casein, IV and VIII). (A) The lipid accumulation in the aorta in ApoE KO mice was examined by staining with H&E (I–IV, 400 × magnification) and (B) Oil Red O (V–VIII, 400 × magnification). An area populated with foam cells is indicated by an arrow in II.