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. 2013 Nov 14;7:209. doi: 10.3389/fncel.2013.00209

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Copyright © 2013 Russo, Nieus, Maggi and Taverna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gap-junction-mediated firing inhibition in FSI pairs stimulated by arrays of sEPSCs in dynamic-clamp configuration. (A) Left, unitary sEPSC conductance (red trace) superimposed to a unitary spontaneous EPSC (black trace) recorded in FSIs in voltage-clamp mode (V_clamp = −70 mV; average of 30 EPSCs recorded in 6 different FSIs). The EPSC waveform was reversed and scaled to that of the sEPSC in order to show matching kinetics (10–90% rise time: 0.3 ms; τ_dec: 0.85 ms). Right, Poisson trains of sEPSCs (300 Hz, 500 ms; segments excerpted from traces lasting 15–20 s) used as dynamic-clamp waveforms. (B) Action potential firing in two GJ-connected FSIs stimulated by sEPSC trains shown in (A) in the presence of 10 μ M gabazine. (C) Summary of PMFR values for GJ-connected and unconnected FSI pairs (n = 6, ^*p < 0.05, Mann-Whitney U test).