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. Author manuscript; available in PMC: 2014 Apr 18.
Published in final edited form as: ACS Chem Biol. 2013 Sep 10;8(10):10.1021/cb400247t. doi: 10.1021/cb400247t

Figure 3.

Figure 3

Comparison of interactions between HE33 and RIα or RIIβ. a) Chemical structure of HE33. b) LiReC Assay results of HE33 activation of RIα and RIIβ. c) Crystal structure of RIα:cAMP2 (tan) and RIα:HE332 (green). Surface rendering of the cyclic nucleotide binding pocket in Domain A (e) and Domain B (f), with HE33 (left) and cAMP (right). d) Crystal structure of RIIβ:cAMP2 (tan) and RIIβ:HE332 (blue). Surface rendering of the nucleotide binding pocket in Domain A (g) and Domain B (h), with HE33 (left) and cAMP (right).