. Author manuscript; available in PMC: 2013 Nov 14.

Published in final edited form as: J Bone Miner Res. 2013 May;28(5):10.1002/jbmr.1792. doi: 10.1002/jbmr.1792

Table 2.

MI Risk Reduction Associated With Bisphosphonate Therapy

Analyses	Subjects	MIs	Model	RR/OR (95% CI)	p
Adjusted for age and sex	5689	101	I: Cox regression (treated patients)	RR 0.53 (0.35–0.81)	0.004
Full model^a	5689	101	I: Cox regression (treated patients)	RR 0.56 (0.37–0.86)	0.009
Adjusted for age and sex	19,281	330	II: Cox regression (all patients)	RR 0.69 (0.52–0.92)	0.011
Full model^a	19,281	330	II: Cox regression (all patients)	RR 0.72 (0.54–0.96)	0.025
Adjusted for age and sex	19,281	340	III: GEE analysis (all patients)	OR 0.71 (0.53–0.95)	0.020
Full model^a	19,281	340	III: GEE analysis (all patients)	OR 0.72 (0.53–0.97)	0.030

Adjusted for age, sex, education, smoking status, household income, marital status, body mass index, diabetes, hypertension, fracture in the last 6 months, lagged fracture in the last 6 months, fracture in the last 5 years, prior MI, bone density determination in last year. Lagged Health Assessment Questionnaire (HAQ), lagged statin, calcium, and prednisone use.

MI = myocardial infarction; RR = relative risk; OR = odds ratio; CI = confidence interval; GEE = generalized estimating equation.