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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Nat Rev Mol Cell Biol. 2013 May 9;14(6):10.1038/nrm3582. doi: 10.1038/nrm3582

Figure 2. Recognition of substrates by F-box proteins.

Figure 2

F-box proteins recognize their substrates in multiple ways. Often, various recognition mechanisms are combined to impart precise regulation of substrate degradation. Eight different modes of recognition and regulation are shown, as discussed in the main text. These simple concepts of regulation and recognition are often combined in substrates. For example, phosphodegron recognition can be combined with priming phosphorylations, or the recognition of non-modified degrons can be paired with restricted degron access.