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. Author manuscript; available in PMC: 2013 Nov 14.
Published in final edited form as: Circulation. 2011 Jan 31;123(6):10.1161/CIRCULATIONAHA.110.973685. doi: 10.1161/CIRCULATIONAHA.110.973685

Figure 5. Differential impacts of PGE2 and PGI2 signaling on VSMC migration.

Figure 5

A: Treatment of WT VSMCs with 10nM cicaprost significantly inhibits cell migration in the scratch wound healing assay. B: Treatment with PGE2 at 28 nM (upper right two panels) promoted WT VSMC migration, compared to vehicle treated cells (upper left two panels), and rescued the impaired migration in the mPGES-1 KO VSMCs. Photos taken at 0 and 24 hours after wounding are shown. C and D are quantifications of cell migration distance in 24hours (A and B, respectively). Representative photos of three independent studies with triplicate treatments in each study are shown.