Table 3.

Advantages and Disadvantages of Biologic Data

Advantages	Disadvantages
May provide novel insights into underlying disease pathophysiologic processes Can serve as an important endpoint of relevance Can be linked to other sociodemographic, medical history, and clinical data to obtain insights into disease occurrence and prognosis	Need to be collected under standardized conditions with considerable attention to detail Ongoing quality control procedures needed Need to consider impact of possible biologic circadian variation for purposes of timing and frequency of data collection efforts May need collection of multiple measures at baseline to adequately profile subsequent changes