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. 2013 Sep 1;188(5):600–607. doi: 10.1164/rccm.201304-0650OC

Figure 1.

Figure 1.

Pharmacokinetic parameters of verapamil in the mouse model. (A) Groups of mice were given a single dose of verapamil orally at different concentrations. Blood samples were withdrawn by cardiac puncture at indicated time points after oral administration. The levels of verapamil were measured by liquid chromatography–mass spectrometry (LC-MS). (B) Mice were given the drugs orally at doses of verapamil of 6.25 mg/kg, rifampin of 10 mg/kg, and rifabutin of 10 mg/kg. Rifampin and rifabutin were given daily to mice for 10 days to reach a steady-state level of metabolizing enzyme, CYP3A. Blood samples were withdrawn by cardiac puncture at indicated time points after oral administration of drugs. (C) Mice were given the drugs orally at indicated doses of verapamil (V) and rifampin (R). The levels of verapamil were measured by LC-MS in the blood samples. Values are expressed as average (±SD).