Figure 4.

Reduction in relapse rates in C3HeB/FeJ mice by adjunctive drug treatment with verapamil. C3HeB/FeJ (A) and C3H/HeJ (B) mice were treated for the indicated time and then the treatment was discontinued for 3 months. Mice were then killed and whole lungs homogenized and plated, and the proportion of mice relapsed was estimated (P < 0.05 for rifampin + isoniazid + pyrazinamide [RHZ] vs. RHZ + verapamil [V] at 16 wk of treatment, Fisher’s exact test). A total of 10 mice was used in the C3HeB/FeJ group, whereas 8 mice were used for C3H/HeJ strain. (C) The percentage of mice relapsing after the treatment in different groups was calculated and depicted in tabular format. −VE = negative; +VE = positive.