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. Author manuscript; available in PMC: 2013 Nov 14.
Published in final edited form as: Nat Struct Mol Biol. 2013 Apr 28;20(6):10.1038/nsmb.2555. doi: 10.1038/nsmb.2555

Figure 2.

Figure 2

Mouse and human tau proteins possess acetyltransferase activity. (a) Immunoblot analysis of heat-stable brain extracts from wild-type (WT) and tau-knockout (KO) mice incubated with CoA or acetyl-CoA, using antibodies to acetyl-lysine, Ac-K280, total tau (T49) and GAPDH. Unboiled brain extracts and GAPDH immunoblotting were used to normalize protein loading (bottom). (b) Immunoblot analysis of highsalt–extracted tau proteins from control and Alzheimer's disease–affected brain, similar to a.