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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Clin Pharmacol Ther. 2013 Apr 25;94(2):10.1038/clpt.2013.83. doi: 10.1038/clpt.2013.83

Table 5.

Health state utilities assigned to treatments and clinical events, and the corresponding duration of acute events.

Parameter Value Probabilistic sensitivity
analysis distribution
Atrial fibrillation (age 67)22 0.774 1-Gamma (43.06,0.005)
Stroke/systemic embolism (permanent disutility)24 0.235 Normal (0.235,0.003)
Stroke/systemic embolism (temporary disutility)22,23 0.139 Normal (0.139,0.01)
Stroke/systemic embolism (temporary disutility, years)23 0.083 Uniform (0,0.183)
Myocardial infarction (permanent disutility)22 0.041 Normal (0.041,0.002)
Myocardial infarction (temporary disutility)22,23 0.125 Normal (0.125,0.01)
Myocardial infarction (temporary duration, years)23 0.083 Uniform (0,0.183)
Intracranial hemorrhage (permanent disutility)22 0.052 Normal (0.052,0.001)
Pulmonary embolism (temporary disutility)22,23 0.139 Normal (0.139,0.01)
Pulmonary embolism (temporary duration, years)23 0.083 Uniform (0,0.183)
Transient ischemic attack (temporary disutility)22,23 0.103 Normal (0.103,0.01)
Transient ischemic attack (temporary duration, years)23 0.014 Uniform (0,0.027)
Major bleed (temporary disutility)22,23 0.139 Normal (0.139,0.01)
Major bleed (temporary duration, years)23 0.083 Uniform (0,0.183)
Minor bleed (temporary disutility)23 0.060 Normal (0.06,0.01)
Minor bleed (temporary duration, years)23 0.014 Uniform (0.0.027)
Warfarin disutility24 0.013 Gamma (1.3,0.01)
Dabigatran/rivaroxaban/apixaban disutility 0.002 Gamma (0.2,0.01)
Aspirin disutility24 0.002 Gamma (0.2,0.01)