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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2013 Jun 3;63:10.1016/j.freeradbiomed.2013.05.028. doi: 10.1016/j.freeradbiomed.2013.05.028

Table I.

Four hour APAP challenge on wild-type mice

GSH+GSSG activity
 TrxR activity
 Trx activity
APAP dose 0 mg/kg 100 mg/kg 1000 mg/kg 0 mg/kg 100 mg/kg 1000 mg/kg 0 mg/kg 100 mg/kg 1000 mg/kg
Value (SEM)1 14.81 (0.89) 14.91 (2.14) 0.68 (0.07) 26.32 (2.34) 20.34 (1.50) 2.43 (0.48) 19.48 (2.08) 17.77 (1.90) 4.83 (1.23)
% of control - 101% 4.5%** - 75.9%* 9.1%** - 91.2% 24.8%**
1

Units for GSH+GSSG levels are nmol · g−1 protein; units for TrxR and Trx activity are both nmol · min−1 · mg−1 protein.

*

P ≤ 0.05;

**

P ≤ 0.01