Table 1. Calculated Thermodynamic Changes (kcal/mol) upon Binding for the Five Tested HIV-1 Protease Inhibitors.

	KB-98	AD-93	KB-92	AD-94	AD-86
ΔG	–24.3	–26.0	–19.8	–19.5	–20.1
ΔH	–46.9	–49.7	–44.5	–45.6	–45.1
–TΔS	22.6	23.7	24.8	26.1	24.96
no. rot. bonds	13	14	15	15	17