Table 1.
Seven glycopeptide signature for MPM in serum
| MPM candidate biomarker N-glycopeptides monitored by SRM* | Protein name | UniProt/Swiss-Prot entry | Gene name | ng/ml** |
|---|---|---|---|---|
|
ADLTVVLLR |
Intercellular adhesion molecule 1 |
P05362 |
ICAM1 |
71 |
|
ALVDFTR |
Basement membrane-specific heparan sulfate proteoglycan core protein |
P98160 |
HSPG2 |
120 |
|
DFDETQLAR |
Anthrax toxin receptor 1 |
Q9H6X2 |
ANTXR1 |
Not available |
|
HADWTLTPLK |
Serum paraoxonase/arylesterase 1 |
P27169 |
PON1 |
22'000 |
|
VIDETWAWK |
Hypoxia up-regulated protein 1 |
Q9Y4L1 |
HYOU1 |
6.6 |
|
VVDSTTGPGEHLR |
Thrombospondin-1 |
P07996 |
THBS1 |
510 |
| KWDVTSLETLK | Mesothelin | Q13446 | MSLN | Not available |
*D replaces the former glycosylated N in the natural peptide sequence after deamidation induced by PNGaseF treatment.
**Concentration in serum/plasma as estimated in PeptideAtlas (ref. Farrah et al. [32]).