Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Assignment of function of active site residues in human ITPA
| Role | Residues |
|---|---|
| Inosine ring stacking | Phe149, Trp151 |
| Inosine specificity | Asp152, Lys172, His177, Arg178 |
| Ribose | Asn16 |
| α-phosphate | Lys19, Glu44/Mg2+, Asp72 |
| β-phosphate | Asn16, Lys19, Glu44/Mg2+, Lys89 |
| γ-phosphate | Thr14, Gly 15, Glu44/Mg2+, Lys56 |
Strictly conserved residues are shown in bold
