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. Author manuscript; available in PMC: 2013 Nov 14.
Published in final edited form as: Am J Transplant. 2011 Aug 9;11(9):10.1111/j.1600-6143.2011.03623.x. doi: 10.1111/j.1600-6143.2011.03623.x

Figure 4. Systemic allospecific effector responses are detectable following orthotopic lung transplant.

Figure 4

(A) Representative flow plots of CD8+ IFN-γ responses at day 10 in mononuclear cells isolated from the native lung, spleen, and mediastinal lymph node of transplanted mice, cultured for 5h in the presence or absence of BALB/c splenocytes (1:1 ratio); gating performed on H-2d negative, CD8+ T cells in mixed cultures. (B) Cumulative day 10 mean allospecific CD8+ IFN-γ responses (expressed as percent of CD8+ cells positive for IFN-γ) from the native lung, spleen, and mediastinal lymph node of mice receiving allografts (n=4–6 mice per group). (p=0.0006 when comparing means of native lung and spleen, and p=0.002 when comparing means of native lung and lymph node.)