Figure 6. Anti-CD154 Ab treatment increases the lung allograft CD4:CD8 ratio and enhances CD4⁺CD25⁺Foxp3⁺ T regulatory cells.

(A) Mean lung allograft CD4:CD8 ratio determined by flow cytometry in anti-CD154-treated mice versus untreated mice (n=4 mice per group). (B) Representative flow plot of CD4⁺CD25⁺Foxp3⁺ T cells in lung allografts from anti-CD154-treated mice versus untreated mice; gating on CD4⁺ cells (n=4 mice per group). (C) Cumulative mean frequency of CD25⁺Foxp3⁺cells as a percent of CD4⁺ T cells in lung allografts from anti-CD154-treated versus untreated mice (n=4 mice per group).