Table 3.
Anti-HIV-1 restriction factor mRNA relative copy number 1
| HIV negative controls | Elite controllers | ART-suppressed | Non-controllers | |
|---|---|---|---|---|
|
APOBEC3A |
9.45 ± 2.3 |
7.95 ± 3.2 |
7.25 ± 1.6 |
10.23 ± 2.9 |
|
APOBEC3B |
2.76 ± 0.5 |
3.230.8 |
4.91 ± 1.2 |
11.65 ± 2.7 |
|
APOBEC3C |
419.62 ± 42.3 |
509.99 ± 38.9 |
393.1 ± 27.1 |
545.81 ± 49.5 |
|
APOBEC3D |
96.42 ± 12.4 |
125.44 ± 11.2 |
92.44 ± 8.7 |
139.17 ± 14 |
|
APOBEC3F |
2 ± 0.3 |
2.73 ± 0.4 |
1.88 ± 0.2 |
3.35 ± 0.4 |
|
APOBEC3G |
66.29 ± 9 |
87.22 ± 7.4 |
67.16 ± 6.6 |
84.02 ± 9.7 |
|
APOBEC3H |
10.88 ± 2.2 |
12.89 ± 2.6 |
12.53 ± 1.6 |
16.74 ± 3 |
|
BST2 |
59.15 ± 9.1 |
81.19 ± 9.9 |
62.31 ± 8.5 |
108.6 ± 16.5 |
|
CDKN1A (P21) |
90.75 ± 25.8 |
74.43 ± 41.1 |
77.39 ± 29.9 |
48.6 ± 11.5 |
|
CTR9 |
170.92 ± 11 |
175.81 ± 11.1 |
146.7 ± 5.6 |
164.3 ± 8.1 |
|
EIF2AK2 |
416.56 ± 11.8 |
359.92 ± 14.5 |
434.52 ± 11.5 |
805.28 ± 8.1 |
|
HERC5 |
179.53 ± 28.7 |
129.72 ± 9.1 |
146.37 ± 22.2 |
250.33 ± 20.9 |
|
IFITM1 |
12102.96 ± 624.2 |
13852.2 ± 778 |
11789.6 ± 1190 |
18163.4 ± 1222.4 |
|
IFITM2 |
2325.19 ± 161.3 |
2442.24 ± 178 |
2256.65 ± 195.9 |
2903.74 ± 239.8 |
|
IFITM3 |
66.43 ± 17.1 |
85.81 ± 13.6 |
97.44 ± 16 |
143.82 ± 20.9 |
|
ISG15 |
17.85 ± 3.7 |
16.82 ± 2.3 |
26.91 ± 8.3 |
56.58 ± 9.1 |
|
MOV10 |
151.25 ± 10.6 |
162.57 ± 14.7 |
137.56 ± 10.6 |
190.16 ± 9.9 |
|
PAF1 |
95.25 ± 3.6 |
98.88 ± 6.4 |
87.55 ± 4.2 |
102.38 ± 6.4 |
|
RNASEL |
34.34 ± 2.9 |
37.96 ± 3.5 |
31.75 ± 2.9 |
34.32 ± 2.5 |
|
RSAD2 (Viperin) |
29.86 ± 12.8 |
23.2 ± 2.5 |
37.11 ± 11.2 |
102.81 ± 15.4 |
|
RTF1 |
322.64 ± 18.2 |
323.08 ± 24.1 |
276.97 ± 16.5 |
322.93 ± 15.7 |
|
SAMHD1 |
1322.37 ± 159.4 |
1420.63 ± 95.8 |
1470.53 ± 78 |
1685.26 ± 92.4 |
|
SLFN11 |
92.4 ± 10.1 |
80.98 ± 10.3 |
54.64 ± 3.4 |
57.44 ± 4.6 |
|
TRIM11 |
85.09 ± 7.4 |
82.25 ± 6.3 |
72.81 ± 6.4 |
97.63 ± 10.1 |
|
TRIM14 |
296.58 ± 25.6 |
351.14 ± 26.8 |
302.04 ± 24 |
460.72 ± 42.5 |
|
TRIM19 (PML) |
180.3 ± 14.5 |
203.55 ± 16.1 |
169.58 ± 13 |
267.52 ± 27.6 |
|
TRIM21 |
128.44 ± 8.9 |
133.74 ± 8.6 |
120.86 ± 10.3 |
148.63 ± 11.1 |
|
TRIM22 |
1547.88 ± 124.4 |
1457.21 ± 93.4 |
1418.98 ± 78.9 |
2049.2 ± 89.4 |
|
TRIM26 |
197.14 ± 16.2 |
188.7 ± 13.3 |
146.16 ± 14 |
201.34 ± 18.4 |
|
TRIM28 |
545.06 ± 27 |
562.97 ± 36.6 |
499.71 ± 32.2 |
527.79 ± 28.5 |
|
TRIM32 |
178.17 ± 12.7 |
173.69 ± 14 |
139.87 ± 7.3 |
180.89 ± 16.9 |
| TRIM5 | 68.18 ± 10.6 | 86.44 ± 7.2 | 77.97 ± 5.7 | 108.67 ± 6.8 |
1Mean ± standard error.