KIT exon 11 codon 557–558 deletion
|
Pathway
|
Negative regulation of cell proliferation
|
Intracellular signal transduction
|
Protein tyrosine kinase phosphatase activity
|
Humoral immune response
|
Cytokine mediated signaling pathway
|
p-value
|
0.09
|
0.10
|
0.11
|
0.13
|
0.13
|
KIT exon 11 other (non-codon 557–8) deletion
|
Pathway
|
Response to stress
|
Negative regulation of apoptosis
|
Protein tyrosine kinase activity
|
Response to Hypoxia
|
T cell receptor signaling pathway
|
p-value
|
0.02
|
0.03
|
0.04
|
0.06
|
0.08
|
KIT exon 11 insertion
|
Pathway
|
Positive regulation of immune response
|
Cytochrome P450
|
Humoral immune response
|
Signal transduction
|
Signal transducer activity
|
p-value
|
0.10
|
0.11
|
0.17
|
0.17
|
0.20
|
KIT exon 11 point mutation
|
Pathway
|
T cell receptor signaling pathway
|
Immune response
|
Positive regulation of cell proliferation
|
Intracellular signal transduction
|
Phase I/II metabolizing
|
p-value
|
0.06
|
0.18
|
0.19
|
0.20
|
0.20
|
Other KIT mutation
|
Pathway
|
AHR/dioxin response
|
G-protein coupled receptor signaling pathway
|
Protein phosphorylation
|
Negative regulation of immune response
|
Cytochrome P450
|
p-value
|
0.01
|
0.06
|
0.08
|
0.08
|
0.09
|
PDGFRA mutation
|
Pathway
|
Defense Response
|
Negative regulation of immune response
|
Protein phosphorylation
|
Positive regulation of immune response
|
AHR/dioxin response
|
p-value
|
0.005
|
0.01
|
0.02
|
0.03
|
0.03
|
Wild type |
Pathway
|
Humoral immune response
|
Defense response to bacteria
|
Transmembrane receptor protein tyrosine phosphatase activity
|
Cytokine receptor activity
|
Response to oxidative stress
|
p-value |
0.02 |
0.11 |
0.13 |
0.14 |
0.14 |