Figure 4. Expansion of ESAT-64–17-Specific Treg Cells Is Context Dependent.
(A) Foxp3 expression and ESAT-64–17:I-Ab tetramer binding within CD4-gated tetramer-enriched pLN of Mtb-infected or Lm-ESAT-6-infected mice at day 21 or day 9 after infection, respectively. Pooled pLNs from each group were enriched for tetramer-binding cells, and the experiment was performed six times for Mtb and three times for Lm-ESAT-6. Numbers represent the percentage of tetramer-binding T cells that express Foxp3.
(B) Cumulative data from six experiments with Mtb-infected and three experiments with Lm-ESAT-6-infected mice are shown. Each circle or triangle represents a time point. See also Figure S4.