Table 1.
Hemodynamic measurements in age matched sham and ACF.
| 6 hrs (n=6) | 12 hrs (n=6) | 2d (n=6) | 5d (n=6) | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Sham | ACF | Sham | ACF | Sham | ACF | Sham | ACF | |
| BW (g) | 291 ±10 | 302 ±5 | 271 ±6 | 267 ±4 | 282 ±16 | 291 ±6 | 284 ±4 | 281 ±4 |
| HW/BW (g/g × 103) | 3.3 ± 0.1 | 3.3 ± 0.1 | 3.4 ± 0.1 | 3.5 ± 0.1 | 3.3 ± 0.1 | 3.9 ± 0.1* | 3.4 ± 0.1 | 4.2 ± 0.1* |
| LVW/BW (g/g × 103) | 2.2 ±0.1 | 2.2 ±0.1 | 2.3 ±0.1 | 2.3 ±0.1 | 2.2 ±0.1 | 2.6 ±0.1* | 2.3 ±0.1 | 2.7 ±0.1* |
| HR (b.p.m) | 385 ±11 | 436 ±18* | 395 ±11 | 419 ±21* | 389 ±9 | 405 ±10* | 365 ±15 | 395 ±5* |
| MAP (mmHg) | 103 ±6 | 85 ±3* | 90 ±5 | 70 ±2* | 76 ±2 | 71 ±2 | 85 ±3 | 74 ±2 |
| LVEDP (mmHg) | 5 ±2 | 7 ±2 | 2 ±1 | 5 ±2 | 2 ±1 | 6 ±1* | 2 ±1 | 7 ±2* |
| LVESP (mmHg) | 58±3 | 72 ±4 | 62 ±2 | 61 ±2 | 66 ±3 | 56 ±3 | 58 ±2 | 71 ±5 |
| LVEDD (mm) | 7.2 ±0.3 | 7.4 ±0.3 | 7.3 ±0.3 | 7.8 ±0.4 | 7.1 ±0.2 | 8.1 ±0.2* | 7.1 ±0.2 | 7.9 ±0.2* |
| LVESD (mm) | 4.2 ±0.3 | 3.8 ±0.4 | 3.8 ±0.2 | 4.1 ±0.4 | 4.0 ±0.2 | 4.1 ±0.3 | 3.9 ±0.3 | 4.1 ±0.5 |
| LVPWTd (mm) | 1.6 ±0.2 | 1.4 ±0.2 | 1.6 ±0.2 | 1.4 ±0.2 | 1.6 ±0.2 | 1.3 ±0.1* | 1.6 ±0.1 | 1.5 ±0.3 |
| LVEDD/LVPWT | 4.4 ±0.4 | 5.1 ±0.5 | 4.5 ±0.5 | 5.2 ±0.2 | 4.6 ±0.2 | 5.9 ±0.3* | 4.4 ±0.4 | 5.3 ±0.2* |
| EF (%) | 65 ±2 | 65 ±3 | 63 ±3 | 66 ±4 | 65 ±3 | 75 ±3* | 64 ±3 | 75 ±3* |
Values are mean ±SEM. BW, Body weight; HW/BW, heart weight to body weight ratio; LVW/BW, LV weight to body weight ratio; HR, heart rate; MAP, mean arterial pressure; LVEDP, LV end-diastolic pressure; LVESP, LV end-systolic pressure; LVEDD, LV end diastolic dimension; LVESD, LV end systolic dimension; LVPWTd, LV posterior wall thickness diastole, LVEDD/LVPWTd; EF, ejection fraction.
*
P< 0.05 vs. age-matched sham.