Table 1.

Subject characteristics and sample sizes.

Feature	Cases	Controls
Swedish sample characteristics
Male sex	0.595	0.512
Median age at sampling	54 (45-62)	57 (48-65)
Median hospital admissions for SCZ or SAD	7 (3-15)	n/a
Median total inpatient days	243 (81-696)	n/a
Median years from first to last HDR admission	9.7 (2.9-19.5)	n/a
Sample sizes
Swedish subjects (Sw1-6)	5,001	6,243
PGC schizophrenia subjects (excluding Sw1-2)	8,832	12,067
Replication results for up to 168 genomic regions	7,413	19,762
Total subjects	21,246	38,072

Values in parentheses are inter-quartile ranges. The case group had significantly more males (p < 0.0001) and was significantly younger (p < 0.0001) than controls although these differences were not of large magnitude. The higher median age in controls is in the direction of greater confidence in control classification (i.e., controls had greater time at risk for psychiatric hospitalization). Cases tended to have had considerable hospitalizations, inpatient lengths of stay, and years of observation. IQQ=interquartile range, SCZ=schizophrenia, SAD=schizoaffective disorder, HDR=Hospital Discharge Register.

All cases and controls are independent. The Swedish sample totals N=11,244, the PGC N=20,899, and the replication samples N=27,175. The Sweden plus PGC meta-analysis is based on N=32, 143. The Swedish sample plus PGC plus replication samples total 59,318. (these counts exclude 511 trios).