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. Author manuscript; available in PMC: 2013 Nov 14.
Published in final edited form as: Biochemistry. 2011 Nov 22;50(50):10.1021/bi200924t. doi: 10.1021/bi200924t

Figure 1. The effect of carbamazepine (CBZ) on midazolam (MDZ) metabolism by CYP3A4 in Supersomes™.

Figure 1

The enzyme normalized velocities (k) of A) 1′-OH midazolam (1′-OH-MDZ) and B) 4-OH midazolam (4-OH-MDZ) formation are shown in the absence (closed squares and solid lines) and presence of 240 μM CBZ (open circles and dashed lines). The ratio of 1′-OH-MDZ versus 4-OH-MDZ formation in the absence (closed squares and solid lines) and presence of 240 μM CBZ (open circles and dashed lines) are illustrated in C).