Figure 9. DUSP1 KO mice are more susceptible to WR infection than WT mice.
DUSP1 WT or KO mice (n = 5) were intranasally (i.n) inoculated with either 5×105 or 5×106 PFU/mouse of WR. A) Mice were (individually) daily weighed and mean percentage weight loss of each group was compared with the weight immediately prior to infection. B) Signs of illness (lack of activity, ruffled fur) were daily evaluated using arbitrary units from 0 to 3 (healthy-ill). C) Survival rate after i.p. inoculation with WR. Different graphs show a representative example of two independent experiments performed. p<0.05 (*), p<0.005 (**) and p<0.001 (***).