Figure 2. A three-protein model for prediction of TGI.

Least Angle Regression (LAR) method identified 3 markers (Ang1, EGF, & Emmprin) sufficient to build a model to predict CVX-060 TGI. Model performance in the training set (A) and testing set (B) of xenograft lines is shown. Statistical significance was not achieved until combining both sets (C). Each dot represents the model predicted TGI% vs. median observed TGI% of a single xenograft line.