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. 2013 Nov 14;8(11):e80290. doi: 10.1371/journal.pone.0080290

Table 3. Comparison of local and central laboratory HER2 testing.

Central Lab, n
Local Labs, n IHC 0/1+, 584 IHC 2+, 86 IHC 3+, 51 HER2 Pos, 78 HER2 Neg, 643 Agreement rate Kappa values (95% CI)
IHC 0/1+, 566 534 32 0 - - 86.7% 0.71 (0.65-0.77)
IHC 2+, 91 47 42 2 - -
IHC 3+, 64 3 12 49 - -
HER2 POS, 86 - - - 72 14 97.2% 0.86 (0.80-0.92)
HER2 NEG, 635 - - - 6 629

 IHC, immunohistochemistry; CI, confidence interval; HER2 POS, HER2-positive, defined as IHC 3+ or IHC 2+/ISH-amplified; HER2 NEG, HER2-negative.