Table 1. Summary of histochemical and immunohistochemical stain results for 4-month WT, 1-, 2-, 4-, 8-, and 12-month LRRK2 KO rats.

Observation (Figure panel)	4-mo. WT Figure 1	1-mo. Lrrk2 KO Figure 2	2-mo. Lrrk2 KO Figure 3	4-mo. Lrrk2 KO Figure 4	8-mo. Lrrk2 KO Figures 5 & 7	12-mo. Lrrk2 KO Figure 6	8-mo. WT Figure 7
Brown pigment	-	-	-	++	+++	++++	NA
H&E (A)	-	-	-	+	+++	++++	NA
Lipofuscin (B)	-	-	-	++	+++	++++	NA
Hyaline droplets	+	-	++	+++	++	++
H&E (A, not as easily identified with this stain)	-	-	+	+	-	-	NA
CAB (C)	+	-	++	+++	++	++	NA
Lysosomes	+	+	++	++	+++	++++	NA
LAMP-1 (D)	+	+	++	++	+++	+++	NA
LAMP-2 (E)	+	+	++	++	+++	++++	NA
NAGLU (F)	+	+	++	++	+++	++++	NA
KIM-1	NA	NA	NA	NA	+++ (KO)	NA	+ (WT)

- not present; + present; ++ +++ ++++ indicate the relative number, size, and/or intensity of a finding as depicted in Figures 1-7.

A = H&E; B = Lipofuscin; C = CAB; D = LAMP-1; E = LAMP-2; F = NAGLU; WT/KO = KIM-1; NA = not applicable