Table 3. Summary of serum chemistry results - Mean Differences (%) for LRRK2 KO rats compared to Long Evans WT.
| Age / Strain |
1 month
|
2 months
|
8 months
|
|||
|---|---|---|---|---|---|---|
| Parameter (Mean±SEM) | Long Evans WT | LRRK2 KO | Long Evans WT | LRRK2 KO | Long Evans WT | LRRK2 KO |
| Cholesterol (mg/dL) | 71±3.9 | 107±4.0** (↑50.7%) | 57±3.3 | 83**±2.7 (↑45.6%) | 56±7.0 | 94±9.8* (↑67.9%) |
| Creatinine (mg/dL) | 0.17±0.013 | 0.18±0.009 (↑5.9%) | 0.19±0.009 | 0.21±0.009 (↑10.5%) | 0.28±0.015 | 0.34±0.013* (↑21.4%) |
| Phosphorous (mg/dL) | 10.6±0.65 | 11.6±0.34 (↑9.4%) | 8.4±0.03 | 10.0±0.26** (↑19.0%) | 6.0±0.17 | 7.0±0.29* (↑16.7) |
| Chloride (mEq/L) | 103±0.6 | 99±0.6** (↓3.9%) | 105±0.5 | 102±0.5** (↓2.9%) | 109±0.6 | 103±0.5** (↓5.5%) |
| Sodium (mEq/L) | 144±0.9 | 143±0.6 (↓0.7%) | 145±0.0 | 144±0.3* (↓0.7%) | 148±0.3 | 144±0.3** (↓2.7%) |
| SDH (U/L) | 9±.3.8 | 11±0.8 (↑22.2%) | 5±0.6 | 12±1.6** (↑140%) | 4±0.6 | 25±1.3** (↑525%) |
* p<0.05; ** p<0.01; ↑ increase compared to WT control; ↓ decrease compared to WT control; SEM Standard Error of the Mean