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. 2013 Nov 14;8(11):e81543. doi: 10.1371/journal.pone.0081543

Figure 5. Possible scenarios for the TAS and the HTT chromatin in a JIL-1 mutant background.

Figure 5

(A) Wild type: the presence of the H3K27me3 mark nucleates a highly repressed chromatin (note the tight packaging of the nucleosomes) in the TAS domain, regulated by the Polycomb group of proteins (Table S1). (B) JIL-1 mutant background: The loss of the JIL-1 boundary, causes a spread of the H3K27me3 mark into the HTT array, resulting in a local decrease of the H3K27me3 mark in the TAS chromatin and as a consequence making this compartment more permissive to gene expression.