Table 5. Stepwise logistic regression analysis in identifying the independent predictors of sustained viral response in patients not achieving rapid viral response.
|
All HCV genotypes
|
HCV genotypes 1/4-5
|
||||||
|---|---|---|---|---|---|---|---|
| O.R. | 95% C.I. | p | O.R. |
95% C.I. | p | ||
| HCV genotypes: 2-3 Vs 1/4-5 | 5.90 | 1.75-19.9 | 0.003 | - | - | - | |
| VDPFA: >5 Vs ≤5 | 4.54 | 1.35-15.3 | 0.018 | 4.48 | 1.19-16.8 | 0.026 | |
| Serum γ-GT IU/mL: ≤80 Vs >80 | 6.89 | 1.47-32.2 | 0.012 | 6.54 | 1.15-37.1 | 0.018 | |
| PEG-IFN-α-2b Vs PEG-IFN α-2a | 4.56 | 1.42-14.6 | 0.030 | 4.51 | 1.25-16.3 | 0.025 | |
| HOMA index < 3 Vs ≥3 | 3.80 | 1.01-14.3 | 0.008 | - | - | - | |
| Cholesterol mg/dL: >200 Vs ≤200 | - | - | - | 5.46 | 1.09-27.5 | 0.034 | |
The variables included in the analysis were those reported in table 2 plus the VDPFA genetic model (>5 Vs ≤5 functional alleles). O.R.=odds ratio, C.I.=confidence interval, IL-28B=interleukin 28B, VDPFA: Vitamin D Pathway Functional Alleles (G for GC rs7041, C for GC rs4588, G for CYP2R1 rs10741657 and T for CYP27B1 rs10877012 loci), PEG-IFN: pegylated interferon; γ-GT=gamma-glutamyl transpeptidase.