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. 2013 Nov 14;8(11):e79651. doi: 10.1371/journal.pone.0079651

Figure 3. Hippocampal-dependent memory deficits are observed in 5–7 month old hAPP mice.

Figure 3

A, Performance in the acquisition portion of the Morris water maze. In the cued platform portion, 2-way repeated measures ANOVA indicates an overall difference between NTG and hAPP mice (p<0.05), but no individual point reached significance in post-hoc tests. There was no significant difference between NTG and hAPP mice in the hidden platform portion of the water maze. B–C, During the probe trial test for memory that occurred 24 hrs after the last training trial of the hidden platform acquisition phase, NTG mice spent more time in the target quandrant relative to the other three quadrants (B) whereas hAPP mice did not (C). D, The latency for hAPP mice to reach the target area for the first time during the probe trial was higher than that for NTG mice. E, Representative paths swum during the probe trial for a NTG and an hAPP mouse. F, Swim speed was similar for NTG and hAPP mice during both the cued and hidden platform portions of the water maze. Swim speeds were compared by assessing the average swim speeds over all sessions in the cued or hidden platform portions of the test. T, target; AR, adjacent right; AL, adjacent left; OP, opposite. n = 12/genotype. *p<0.05.