Figure 5. MHY908 attenuated ER stress induced insulin resistance in the livers of db/db mice.

(A) Results of Western-blot analysis of the livers of db/db mice; the ER stress markers p-IRE, p-PERK, and p-JNK are shown. CR and MHY908 decreased ER stress marker protein levels in db/db livers, and (B) CR and MHY908 improved insulin signaling in db/db livers. Lean; db/m mice, Con; db/db mice, CR; calorie restriction, 1 mg; MHY 908 1 mg/kg/day, 3 mg; MHY 908 3 mg/kg/day.