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Cytotoxicity and radiosensitizing effect of bortezomib. (A) Clonogenic survival after exposure of SK-N-BE(2c) cells or UVW/NAT cells to bortezomib for 24 h. Clonogenic survival of (B) SK-N-BE(2c) cells and (C) UVW/NAT cells simultaneously exposed to X-radiation and 3 or 5 nM bortezomib for 24 h. Data are means ± SEM, n = 4; significance of differences: * p < 0.05, ** p < 0.01 from untreated control, † p < 0.05, †† p < 0.01 from radiation treatment alone.
