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. 2013 Nov 13;3:73. doi: 10.1186/2191-219X-3-73

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Copyright © 2013 Rae et al.; licensee Springer.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of bortezomib alone or combined with ¹³¹I-MIBG/topotecan on the growth delay of experimental tumours. Growth of human tumour xenografts derived from (A) SK-N-BE(2c) cells or (B) UVW/NAT cells in athymic mice exposed to PBS, bortezomib alone (0.8 mg/kg), ¹³¹I-MIBG (18 or 5 MBq for SK-N-BE(2c) or UVW/NAT, respectively) + topotecan (1.75 or 0.875 mg/kg for SK-N-BE(2c) or UVW/NAT, respectively) or the combination of bortezomib with {¹³¹I-MIBG + topotecan}. Data are expressed as mean tumour volume at every time point (mm³) ± SD. Abbreviations: BZ, bortezomib; M/T, ¹³¹I-MIBG and topotecan administered simultaneously.