Table 4.
MMP/TIMP ratios for the study and control groups
| CONTROL | POAG | PXS | PXG | |
|---|---|---|---|---|
|
MMP2/TIMP1 |
0,464 ± 0,1 |
0,805 ± 0,31 (p > 0.1) |
0,73 ± 0,753 (p > 0.1) |
0,618 ± 0,360 (p > 0.1) |
|
MMP2/TIMP2 |
2,07 ± 0,65 |
4,04 ± 2(p = 0.069) |
2,8 ± 1,09 (p = 0.06) |
4,34 ± 3,59 (p = 0.06) |
|
MMP2/TIMP4 |
18,42 ±8,4 |
33,54 ± 25,61 (p = 0.031) |
34,47 ± 19,07 (p < 0.001)* |
28,36 ± 26,88 (p = 0.73) |
|
MMP3/TIMP1 |
0.21 ± 0,085 |
0.17 ± 0.2 (p = 0.001)* |
0.226 ± 0.4 (p < 0.001)* |
0.26 ± 1.15 (p = 0.02) |
|
MMP3/TIMP2 |
0.95 ± 0.48 |
0.88 ± 1.16 (p = 0.007)* |
1.68 ± 3.17 (p = 0.01)* |
2.07 ± 3.9 (p = 0.39) |
|
MMP3/TIMP4 |
8,47 ± 4,86 |
11,93 ± 24,07 (p > 0.1) |
14,16 ± 31,4 (p > 0.1) |
16,85 ± 40,98 (p > 0.1) |
|
MMP9/TIMP1 |
0.028 ± 0.014 |
0.023 ± 0.017 (p < 0.001)* |
0.02 ± 0.019 (p < 0.001)* |
0.02 ± 0.018 (p < 0.001)* |
|
MMP9/TIMP2 |
0.13 ± 0.07 |
0.104 ± 0.059 (p < 0.001)* |
0.12 ± 0.06 (p < 0.001)* |
0.104 ± 0.063 (p < 0.001)* |
| MMP9/TIMP4 | 1.18 ± 0.99 | 1,12 ± 1.08 (p = 0.01)* | 1.42 ± 0.7 (p = 0.4) | 0.8 ± 0.59 (p < 0.001)* |
MMP: Matrix metalloproteinase, TIMP: Tissue inhibitor metalloproteinase, POAG: Primary open angle glaucoma, PXS: Pseudoexfoliation, PXG: Pseudoexfoliation glaucoma.
Values are presented as mean ± SD.
p values refer to the Mann Whitney test for each study group versus controls. Statistical significance: p < 0.01 after Bonferroni correction.
*: statistically significant.